Seminarium Zakładu Biofizyki

Combating antibiotic-resistant pathogens has become one of the greatest challenges facing modern science. The overuse of antibiotics has led to a sharp increase in bacterial resistance, particularly after the COVID-19 outbreak. As a result, the development of new, effective antibacterial agents is crucial. Membrane-active peptides hold significant potential for creating new antimicrobials. However, their therapeutic use is limited by factors such as susceptibility to proteolytic degradation and potential toxicity to mammalian cells.By stabilizing the conformations of membrane-active peptides and adapting their specific properties, we have been able to mitigate these limitations. The peptides we have modified show activity against both Gram-negative and Gram-positive strains and are non-hemolytic. Our findings pave the way for designing new classes of amphipathic peptides and will contribute to the development of novel antibacterial agents