Seminarium Zakładu Biofizyki

Glioblastoma (GBM) is the most common and aggressive primary brain tumor, with current therapeutic approaches often failing to deliver durable clinical benefits. This highlights the urgent need for innovative treatment strategies. Targeted therapies employing the "Trojan Horse" approach have emerged as a promising avenue, offering the potential to improve specificity and reduce side effects by focusing on tumor-specific antigens.This presentation outlines the preclinical advancements of immunotoxins developed by WPD Pharmaceuticals, specifically designed to target overexpressed proteins such as IL-13RA2 and EphA2—markers frequently found in glioblastoma cells but absent in normal brain tissue. Initial studies demonstrate these immunotoxins' ability to inhibit tumor cell growth and induce apoptosis in receptor-positive GBM cells. The integration of innovative delivery methods, including intracerebral administration and composite carriers, further enhances drug precision and effectiveness. Moreover, combination therapy approaches that pair these immunotoxins with other drugs are being explored to maximize therapeutic outcomes.This pioneering work underscores the potential of the “Trojan Horse” strategy in transforming the treatment landscape for GBM, offering hope for improved patient outcomes through highly specific and locally delivered therapeutic interventions.

Dr Angelika Kaczyńska is a highly qualified biotechnologist specializing in innovative anti-cancer therapies. Dr Kaczyńska earned her PhD with distinction from the University of Gdańsk, where she focused on combination therapies for breast cancer. She has extensive experience in the pharmaceutical industry, particularly in managing research and development (R&D) projects. Since 2018, she has been affiliated with WPD Pharmaceuticals, where she holds the position of Project Manager. She graduated with distinction from the postgraduate studies Academy of Management Excellence at Koźminski University. Dr Kaczyńska is the author of numerous scientific publications and conference presentations. She is a recipient of multiple awards for scientific achievements, including the InnoDoktorant Award, the We Educate the Best Award, the Jerzy Masłowski Award, the Gullapalli Young Investigator Award, and a scholarship co-funded by UNESCO.