Seminarium Zakładu Biofizyki

Glioblastoma multiforme (GBM, glioblastoma multiforme) is the most common and aggressive primary brain tumour, characterised by rapid growth, high invasiveness and high genetic diversity. Current therapeutic approaches, including surgery, radiotherapy and chemotherapy, although being intensively developed, often do not provide sustained clinical benefit. The average survival time for patients from diagnosis is only 12-18 months, highlighting the urgent need to develop innovative and more effective treatment strategies for this cancer.This seminar will discuss a variety of methods using ionising radiation in cancer therapy, with a particular focus on alpha particles. Alpha radiation, characterised by high linear energy transfer (LET), has unique therapeutic potential as these particles induce complex and difficult to repair DNA damage. This makes them particularly effective in eliminating cancer cells resistant to conventional therapies such as X-rays and electrons.Radiobiological issues will also be addressed, including differences in the mechanisms of DNA damage induced by alpha radiation compared to low LET radiation. Particular attention will be paid to dosimetric aspects, which are key to accurately delivering radiation doses to tumour sites while minimising damage to healthy tissue. Examples of the use of alpha radiation in modern therapeutic strategies will also be discussed, which may represent an important step in the treatment of glioblastoma multiforme.

Bio: Dr Agnieszka Korgul, Prof. UW, is an employee of the Department of Nuclear Physics, Faculty of Physics, University of Warsaw, with over 20 years of experience in research and teaching in nuclear physics. She collaborates with renowned research centres such as CERN, GSI, ORNL, MSU and RIKEN. She has authored more than 100 publications in Philadelphia-listed journals. She is also President of the Polish Nucleonic Society. Her research focuses on basic research, among others, related to nuclear medicine and dosimetry.