Seminarium Zakładu Biofizyki

The cellular proteome and its organisation are remarkably complex. To maintain a homeostasis, cell must carefully balance its proteome by controlling protein quality and abundance.My lab is interested in the molecular basis of proteostasis with focus on protein clearance pathways in the context of human diseases. Protein degradation is a key mechanism to adapt protein levels to cellular or environmental changes. Efficient protein removal is crucial to avoid accumulation of misfolded and toxic protein species. The decline in protein clearance pathways is a key driver of age-related cellular dysfunction and accumulation of toxic protein species is associated with neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.Maintenance of cellular proteostasis requires temporally and spatially controlled degradation of regulatory and erroneous proteins through ubiquitin-proteasome system and autophagy-lysosomal pathway. My lab focuses on understanding how ubiquitin-proteasome system is regulated in different cellular compartments and how does it crosstalk with autophagy. We also study the mechanisms regulating the nucleocytoplasmic trafficking of proteins important for cellular proteostasis.