Seminarium z fizyki biologicznej i bioinformatyki

link do spotkania: https://zoom.us/j/91976153012?pwd=azNiMWE4UnhPN3lRQlY2UHZHOXVkQT09

Classical structural biology explains protein function primarily throughstable and well-defined molecular structures. While this paradigm successfully describes many biological processes, increasing evidence suggests that the cellular context in which proteins operate can be equally important in determining their activity. These effects appear to be particularly important in the regulation of gene expression in eukaryotic cells. Biochemical and biophysical studies indicate that complex regulatory phenomena can emerge from transient interactions, structuralheterogeneity, and cooperative network behavior, pointing toward a moredynamic view of cellular organization associated with protein quinary structure.Many transcription factors contain intrinsically disordered regions(IDRs) that mediate interactions with DNA, proteins, and the surrounding cellular environment. In such systems, regulation emerges not from single stable complexes but from the collective behavior of dynamically reorganizing interaction networks. Particular attention will be given to the transcription factors YY1 and YY2, whose intrinsically disordered regions enable flexible interactions with DNA and protein partners, contributing to context-dependent control of gene expression.