Seminarium z fizyki biologicznej i bioinformatyki

link do spotkania: https://zoom.us/j/91976153012?pwd=azNiMWE4UnhPN3lRQlY2UHZHOXVkQT09

There is a critical need for new antibiotics to treat bacterial infections caused by pathogens that are resistant to many, if not all, currently available drugs. Here, we present a method for identifying a prospective new antibiotic by first developing a dedicated assay and then using it for high throughput screening of a chemical compound library. The screen was designed to detect inhibition of the formation of the “ternary complex,” a structure essential for bacterial protein synthesis in all bacteria, composed of elongation factor Tu (EF-Tu), aminoacyl-tRNA, and GTP. The inhibitory compound, designated MGC-10, was effective against all Gram positive bacteria tested, including a wide variety of methicillin resistant Staphylococcus aureus (MRSA) strains. Although apparently too toxic for systemic use, the compound was safe and effective for topical treatment of skin infections in a mouse model. No resistance to the compound has been detected thus far, suggesting strong potential for treating infections caused by pathogens resistant to existing antibiotics.