Soft Matter and Complex Systems Seminar

Nowadays we observe enormous development of chromatin structure studying techniques such as high-throughput sequencing (Hi-C), Chromatin Interaction Analysis by Paired-End Tag Sequencing (ChIA-PET) or HiC Chromatin Immunoprecipitation (Hi-ChIP). Together with the development of genomic techniques there is also rapid development of direct 3D microscopic imaging of nucleus internal structure, both light microscopy (STORM, iPALM) and electron microscopy (Chrom-EMT, EM-ISH).
The amount of available data allows us to develop explore 3D modelling techniques on detail level never available before. In my seminar I'll review briefly types of presently available data sets, and describe their usability for modelling purposes. Then I'll present few types of modelling approaches we tested in our lab, and in the end I'll show our most recent tools devoted for chromatin modelling.