Seminarium z fizyki biologicznej i bioinformatyki

Medical application of nanotechnology and nanomedicine is a broad field of research describing the use of nanomaterials to combat a number of diseases, including cancers. Despite the variety of approaches available, there is still a lack of strategies offering quantitative analysis to assess the suitability of new compounds or nanoparticles as potential therapeutic agents. The key issue is therefore to establish appropriate models and tools that could be applied in preclinical research to assess the advances made in nanomedicine. To address this need, I focus my research on developing new fluorescence-based methods for studying the transport of drugs: in tissues, through the cell membrane and inside the cell. The devised methodologies allow to measure the mobility of any fluorescent molecule in the extracellular spaces of tumour models, the cellular uptake kinetics of drugs or drug carriers, and characterize drug-target interactions.